Ask your doctor if these medicines affect your ability to take ibuprofen. ACE Inhibitors Angiotensin-converting enzyme ACE inhibitors, which may be used for wirh or heart disease, include lisinopril and enalapril. Doctors and researchers initially believed that this phenomenon was an allergic response to aspirin. These include zafirlukast Accolate, montelukast Singulair, and zileuton Zyflo. The bottom line.
For the vast majority of persons with asthma, taking aspirin has no effect on their asthma, either good or bad. Besides causing symptoms of asthma, aspirin can cause nasal congestion and abdominal pains in susceptible individuals. Most often, this sensitivity to aspirin develops in adulthood. It often is found in conjunction with nasal polyps growths of extra nasal tissue that plug the nasal passageways. Many persons with asthma have been advised by their physicians to avoid aspirin because of their asthma.
Aspirin exacerbated respiratory disease AERD, also termed aspirin-induced asthma,  is a medical condition initially defined as consisting of three key features : asthma, respiratory symptoms exacerbated by aspirin and other nonsteroidal anti-inflammatory drugs NSAIDs, and nasal polyps. Most commonly the first symptom is rhinitis inflammation or irritation of the nasal mucosa, which may manifest as sneezing, runny nose, or congestion. The disorder typically progresses to asthma, then nasal polyposis, with aspirin sensitivity coming last. Anosmia lack of smell also is common, as inflammation within the nose and sinuses likely reaches the olfactory receptors. The respiratory reactions to NSAIDs vary in severity, ranging from mild nasal congestion and eye watering to lower respiratory symptoms including wheezing, coughing, an asthma attack, and in rare cases, anaphylaxis. In addition to aspirin, patients also react to other NSAIDs such as ibuprofen, and to any medication that inhibits the cyclooxygenase-1 COX-1 enzyme, although paracetamol acetaminophen in low doses  is generally considered safe.