Signaling molecule may prevent Alzheimer’s

New research in humans and mice identifies a particular signaling molecule that can help modify inflammation and the immune system to protect against Alzheimer’s disease. The work, which was led by investigators at Harvard-affiliated Massachusetts General Hospital (MGH), is published in Nature. Cognitive decline associated with Alzheimer’s disease develops when neurons begin to die. “Neuron death… Read More »

Kadmon’s Rezurock scores surprise FDA nod in chronic graft-versus-host-disease

With a surprise FDA approval Friday afternoon, Kadmon Holdings is on its way to becoming a commercial drugmaker.  The FDA cleared Kadmon’s Rezurock to treat chronic graft-versus-host disease, a serious complication of transplant procedures. Formerly known as belumodsil, the drug is a first-in-class ROCK2 inhibitor—and now Kadmon’s first approved drug.  GVHD occurs when donor cells mount an immune response against a patient’s own tissues and organs. While doctors can… Read More »

Essential Reads: Neurosteroids, Allopregnanolone and Vulnerability to Depression in Women

Essential Reads: Neurosteroids, Allopregnanolone and Vulnerability to Depression in Women Women are twice as likely as men to suffer from a depressive disorder.  In addition, they are vulnerable to mood disorders associated with reproductive functioning, specifically premenstrual dysphoric disorder, perinatal depression, and perimenopausal depression. There is strong evidence to indicate that biological factors (genetic vulnerability,… Read More »

If I Don’t Sweat, Does It Even Count?

It is a common belief that if you don’t leave a workout dripping in sweat, it didn’t count. Count for what? That is the main question. If you didn’t sweat until your clothes need to be wrung out, does that mean it was a waste of time?  Before we talk about the physiology of sweating,… Read More »