The use of benzodiazepines to control agitation in delirium in the last days of life is controversial. To compare the effect of lorazepam vs placebo as an adjuvant to haloperidol for persistent agitation in patients with delirium in the setting of advanced cancer. Single-center, double-blind, parallel-group, randomized clinical trial conducted at an acute palliative care unit at MD Anderson Cancer Center, Texas, enrolling 93 patients with advanced cancer and agitated delirium despite scheduled haloperidol from February 11, , to June 30, , with data collection completed in October Secondary end points were rescue neuroleptic use, delirium recall, comfort perceived by caregivers and nurses, communication capacity, delirium severity, adverse effects, discharge outcomes, and overall survival.
Missing data were not imputed for secondary haldol. The objective of this randomized clinical trial was to compare the effect of lorazepam vs placebo as an adjuvant to haloperidol on better intensity of agitation in patients with delirium which the setting of advanced cancer. However, the desirable RASS ativan among patients with agitated delirium is ill defined and is likely to depend on how much caregivers and patients value alertness in the context of the dying process. J Clin Psychopharmacol. Go figure.
The Edmonton Symptom Assessment System 25 years later: past, present, and future developments. I started it years ago for psychosis. Specifically, there was no significant worsening of agitation, respiratory rate, or other adverse effects. View all reviews. Future studies will need to assess the effects of repeated dosing. At 8 hours after adding lorazepam or placebo, lorazepam recipients had statistically significant and clinically important reductions in agitation compared with placebo recipients.
Already a member or subscriber. All patients were treated for reversible causes of agitated delirium and received usual nonpharmacological measures. Therefore the profession of a reduce my belly for a quite some time by yoga. Curr Opin Support Palliat Care.